12.02.2012 18:00:43
INDORE : In yet another complaint against the unethicaldrug trials that took place in the city, a local resident lodged a complaint with the Drug Controller General of India (DCGI , Medical Council of India (MCI and National Human Rights Commission on Saturday accusing some city-based doctors with a clinic of making his son a trial subject after keeping him in the dark.
Om Prakash Agrawal, a resident of Rajmohalla here, alleged that the people involved in the controversial drug trials kept him in the dark. He alleged that the drug had severe side-effects and the health condition of his son, Nitin, continued deteriorating. "After my son failed in examination, his mental health became unstable. He was not a healthy volunteer. Then, how could the doctors conduct trial on him," asked Agrawal.
The complainant stated that a medical store owner referred him to Dr Abhay Paliwal at his clinic in Geeta Bhawan. "Nitin was admitted in May 2010 and we were told that he would be alright in a few days. They asked me to sign on some forms, which were in English. Though I could not understand the content, I signed on it trusting the doctors. My son was admitted to the hospital for 10 days," stated Agrawal in his complaint.
Informing that the 'treatment' did not yield any result as per the promise, Agrawal complained that the doctors used to take blood samples 8-10 times a day.
"We even opposed when doctors collected blood samples frequently but no one listened," alleged Agrawal.
The complaint alleged that an Ahmedabad-based company, Intas, sponsored the trial for which approval was taken from city-based Naitik independent ethics committee and ethics committee of CHL-Apollo Hospital.
Nitin was also not insured against clinical trial liability and is still taking the medicines for his ailment. He was not given patient information sheet and a copy of informed consent form, the complainant added.
However, the doctor involved in the particular case clarified that no trial was conducted without informing patient or family member. "I do not remember the case. I have to check the records. However, no trial was conducted without taking consent of the patient or family members," added Dr Paliwal.
After my son failed in examination, his mental health became unstable. Then, how could the doctors conduct trial on him.
http://timesofindia.indiatimes.com/articleshow/11855229.cms
13.02.2012 12:59:01
Cantaloupe is valued for its sweet, juicy flesh, an excellent source of vitamin C. In the state of Colorado, the melon is big business, with more than 2,000 acres under cantaloupe cultivation and an annual crop worth nearly $8 million.
Hugh Maguire, PhD, a senior microbiologist with the Colorado Department of Public Health & Environment (CDPHE , said, "People in this area look forward to the end of summer when local cantaloupe becomes available."
Late last summer, Maguire learned that cantaloupe can also be a vehicle for one of the nastier foodborne bacteria: Listeria monocytogenes. In fact, cantaloupe and L. monocytogenes are a particularly bad combination, as the bacteria thrive in the refrigerator, where the melon is likely to be stored, and the simple act of slicing the fruit is sufficient to spread the bugs from rind to flesh.
In a typical year, the DPHE laboratory receives two patient specimens per month that test positive for L. monocytogenes. So when the laboratory confirmed nine cases of L. monocytogenes infection between August 28 and September 2, red flags went up.
Using two DNA 'fingerprinting' techniques--PFGE and MLVA--Colorado scientists quickly determined that the patients could be assigned to one of three unique clusters, each with a Listeria bug with a different and distinct genetic 'fingerprint.' This information was crucial, as each cluster represented a potential outbreak source.
State epidemiologists interviewed cluster patients to look for common food exposures. On September 7, they contacted the laboratory and, said Maguire, "asked if we could purchase cantaloupe from retail sites and test it for the presence of L. monocytogenes. Would we be able to find it if it were there? And the answer was, 'Yes, we'll get on it.'"
??Would we be able to find it if it were there? And the answer was, 'Yes, we'll get on it.'?Senior Microbiologist, Colorado Department of Public Health & Environment (CDPHE At the same time, investigators had a fortuitous break: one of the patients had purchased two cantaloupes, one stored as cut chunks in the refrigerator and the other still uncut. The scientists prepared to test these immediately, while two staff members went grocery shopping. The pair went to three stores--one outlet of store A and two outlets of store B--returning with 15 Colorado-grown cantaloupes.
In the meantime, the patient count continued to rise. Speed was all important.
"We fast-tracked everything to the limits of the protocol," said Maguire. "If the protocol said incubate for four to 16 hours, we incubated for four hours on the dot."
The scientists performed PFGE analysis in parallel with MLVA, both running at max speed.
They bagged each cantaloupe with an enrichment broth and let it incubate. Then they plated the broth on agar growth media and waited for dark blue dots to appear, a tell-tale sign of Listeria.
Working over the weekend, food microbiologist Skip Gossack recovered and confirmed those Listeria colonies, while molecular biologist Justin Nucci, MPH, initiated MLVA.
The results? All five melons from store A tested negative for L. monocytogenes. All ten from store B tested positive. This information alone, said Maguire, exonerated some cantaloupe farms on the list of suspected sources.
Even more importantly, all of the distinct Listeria fingerprints associated with patient isolates were represented in the isolates from store B cantaloupes. Maguire said, "This eliminated concerns that there might be an alternate source of Listeria. Everything we were seeing in the patients, we were seeing in the cantaloupe."
The PFGE data, coming a day or so later, was "100% concordant" with MLVA data.
As the link to cantaloupe developed, regulators were already busy with traceback investigations. Ultimately, they identified one farm as the sole source. On September 14, the farm issued a voluntary cantaloupe recall.
However, since L. monocytogenes can incubate for up to 70 days before onset of illness, cases continued to mount. By September 29, 84 cases from 19 states were reported to the CDC, among them, 15 deaths.
The good news is that the contamination did not occur three years earlier, before the CDPHE laboratory had the benefit of cooperative agreement funding from the US Food and Drug Administration and Food Emergency Response Network. Maguire said, "Without this support, the instrumentation, training and collaborative relationships [critical to breaking the investigation] would not have existed, because we wouldn't have had the money to put them in place."
Instead, with the infrastructure up and running, the laboratory moved quickly. Maguire said it met its major challenge: "how to identify a dangerous product but not impact the entire Colorado cantaloupe industry."
Colorado Department of Public Health & Environment, Laboratory Division Scientific Team Responsibl?e for Testing During the Listeria Outbreak, October 2011. (Left to right Garth Summers (temporary?-Molecular lab , Kristin Mayo (lab technician?-Molecular lab , Skip Gossack (scientist?-Environme?ntal Microbiolo?gy lab , Margot Stuchin (APHL fellow-Mol?ecular lab and Justin Nucci (scientist?-Molecular lab . -- APHL photo-------------------
"Success Stories: A Colorado Cantaloupe Saga" is reposted, with permission, from the
Association of Public Health Laboratories website.
Hugh Maguire, PhD, a senior microbiologist with the Colorado Department of Public Health & Environment (CDPHE , said, "People in this area look forward to the end of summer when local cantaloupe becomes available."
Late last summer, Maguire learned that cantaloupe can also be a vehicle for one of the nastier foodborne bacteria: Listeria monocytogenes. In fact, cantaloupe and L. monocytogenes are a particularly bad combination, as the bacteria thrive in the refrigerator, where the melon is likely to be stored, and the simple act of slicing the fruit is sufficient to spread the bugs from rind to flesh.
In a typical year, the DPHE laboratory receives two patient specimens per month that test positive for L. monocytogenes. So when the laboratory confirmed nine cases of L. monocytogenes infection between August 28 and September 2, red flags went up.
Using two DNA 'fingerprinting' techniques--PFGE and MLVA--Colorado scientists quickly determined that the patients could be assigned to one of three unique clusters, each with a Listeria bug with a different and distinct genetic 'fingerprint.' This information was crucial, as each cluster represented a potential outbreak source.
State epidemiologists interviewed cluster patients to look for common food exposures. On September 7, they contacted the laboratory and, said Maguire, "asked if we could purchase cantaloupe from retail sites and test it for the presence of L. monocytogenes. Would we be able to find it if it were there? And the answer was, 'Yes, we'll get on it.'"
??Would we be able to find it if it were there? And the answer was, 'Yes, we'll get on it.'?Senior Microbiologist, Colorado Department of Public Health & Environment (CDPHE At the same time, investigators had a fortuitous break: one of the patients had purchased two cantaloupes, one stored as cut chunks in the refrigerator and the other still uncut. The scientists prepared to test these immediately, while two staff members went grocery shopping. The pair went to three stores--one outlet of store A and two outlets of store B--returning with 15 Colorado-grown cantaloupes.
In the meantime, the patient count continued to rise. Speed was all important.
"We fast-tracked everything to the limits of the protocol," said Maguire. "If the protocol said incubate for four to 16 hours, we incubated for four hours on the dot."
The scientists performed PFGE analysis in parallel with MLVA, both running at max speed.
They bagged each cantaloupe with an enrichment broth and let it incubate. Then they plated the broth on agar growth media and waited for dark blue dots to appear, a tell-tale sign of Listeria.
Working over the weekend, food microbiologist Skip Gossack recovered and confirmed those Listeria colonies, while molecular biologist Justin Nucci, MPH, initiated MLVA.
The results? All five melons from store A tested negative for L. monocytogenes. All ten from store B tested positive. This information alone, said Maguire, exonerated some cantaloupe farms on the list of suspected sources.
Even more importantly, all of the distinct Listeria fingerprints associated with patient isolates were represented in the isolates from store B cantaloupes. Maguire said, "This eliminated concerns that there might be an alternate source of Listeria. Everything we were seeing in the patients, we were seeing in the cantaloupe."
The PFGE data, coming a day or so later, was "100% concordant" with MLVA data.
As the link to cantaloupe developed, regulators were already busy with traceback investigations. Ultimately, they identified one farm as the sole source. On September 14, the farm issued a voluntary cantaloupe recall.
However, since L. monocytogenes can incubate for up to 70 days before onset of illness, cases continued to mount. By September 29, 84 cases from 19 states were reported to the CDC, among them, 15 deaths.
The good news is that the contamination did not occur three years earlier, before the CDPHE laboratory had the benefit of cooperative agreement funding from the US Food and Drug Administration and Food Emergency Response Network. Maguire said, "Without this support, the instrumentation, training and collaborative relationships [critical to breaking the investigation] would not have existed, because we wouldn't have had the money to put them in place."
Instead, with the infrastructure up and running, the laboratory moved quickly. Maguire said it met its major challenge: "how to identify a dangerous product but not impact the entire Colorado cantaloupe industry."
Colorado Department of Public Health & Environment, Laboratory Division Scientific Team Responsibl?e for Testing During the Listeria Outbreak, October 2011. (Left to right Garth Summers (temporary?-Molecular lab , Kristin Mayo (lab technician?-Molecular lab , Skip Gossack (scientist?-Environme?ntal Microbiolo?gy lab , Margot Stuchin (APHL fellow-Mol?ecular lab and Justin Nucci (scientist?-Molecular lab . -- APHL photo-------------------
"Success Stories: A Colorado Cantaloupe Saga" is reposted, with permission, from the
Association of Public Health Laboratories website.
13.02.2012 21:54:35
Supply of key drug to treat childhood leukemia may run out in weeks
The New York Times
Published Feb 13, 2012 12:54PM MDT
A crucial medicine to treat childhood leukemia is in such short supply that hospitals across the country may exhaust their stores within the next two weeks, leaving hundreds and perhaps thousands of children at risk of dying from a largely curable disease, federal officials and cancer doctors say. “This is dire,” said Valerie Jensen, associate director of the Food and Drug Administration’s drug shortages program. “Supplies are just not meeting demand.” Methotrexate is the drug, and the cancer it...
Copyright 2012 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
14.02.2012 0:45:25
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The price factor associated with this medication affects the brand medication sales as this medication is very low in cost. Malegra treats impotence problems . This medication is effective and available in bulk at many online pharmacy stores. Malegra is a blessing for couples who were earlier unable to enjoy the fruits of life.
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